Referring Doctors
Mehmet A Eskan DDS PhD LLC
Clinician, Researcher, and Educator
Diplomate, American Board of Periodontology
& Dental Implant Surgeon
Dr. Eskan is a Board-Certified Periodontist and Dental Implant Surgeon interested in advanced surgical periodontics and implant therapy techniques. Dr. Eskan completed his DDS with an honorary degree and was awarded the University of President Highest Achievement Award
Following graduation, he was admitted to the University of Louisville where he completed his specialist training in Periodontics and Dental Implantology and also received his Ph.D. in Microbiology and Immunology. Dr Eskan earned his double degree, residency and PhD, in 3 years. Dr. Eskan was one of the recipients of the Tarrson Regeneration Scholarship by the American Academy of Periodontology. Dr. Eskan also won the Prestigious Billy M. Pennel Research Competition for his clinical research in bone regeneration. He has been practicing over 10 years as a periodontist and implant surgeon.
Dr. Eskan currently serves as a faculty member at NSU College of Dental Medicine and the University at Buffalo School of Dentistry in the Department of Periodontics. He has published a large amount study in journals with high impact factors. Dr. Eskan’s Ph.D. thesis was selected as a featured article and became cover of the Nature Immunology in May 2012. He was very first dentist who published in the Nature Immunology and became its cover. His recent study was featured all around the world on numerous web pages including Futurity, University of Buffalo, Medical News Today, Dental Tribune, The Daily Science, Med India and Medical Daily, etc. His recent clinical research hit a score of more than 321 on social media and was also on the news (CNBC, 2WZGR). His publications have been featured more than 2600 times by other researchers so far. Dr. Eskan has given a great number of lectures internationally. He led ProArch (also called All-on-4), Guidor Membrane applications in bone regeneration, and Osseodensification.
Memberships:
- AAP, American Academy of Periodontology
- MSP, Midwest Society of Periodontology
- CDS, Chicago Dental Society
- ADEA, American Dental Education of Association
- ADA, American Dental Association
- ISOP, Illinois Society of Periodontics
- ABP, American Board of Periodontology
Awards:
- 2017: A Fixed Reconstruction of Complete Edentulous Patient with Immediate
Function Using a New Implant Design: A Retrospective Clinical, Funded by Straumann
- 2017: The ProArch Centers of Excellence by Straumann (Lisbon, Portugal)
- 2017: Expert Panel Meeting by Sunstar (Madrid, Spain)
- 2016: A treatment option in the edentulous patients, chosen one of the six cases in the world (By Straumann)
- 2011: The Prestigious Billy M. Pennel Research.
- Southern Academy of Periodontology (Florida, USA)
- 2008: The Dean’s Scholarship
- University of Louisville School of Dentistry (Kentucky, USA)
- 2008: Tarrson Regeneration Scholarship awarded by the American Academy of Periodontology
(this award is given two people every three years, Washington, USA)
- 1998: Former President Honor Award
- Hacettepe University (Ankara, TURKEY)
- 1997: First Place Award
- Hacettepe University (Ankara, TURKEY)
- 1997: President’s Superior Achievement Award
- Hacettepe University (Ankara, TURKEY)
- 1997: Achievement Award from Turkish Dental Association
- 1997: Dean’s Award for highest academic achievement
- Hacettepe University School of Dentistry (Ankara, TURKEY)
Licensure
- Licensed Dentist: State of Texas
- Licensed Dentist: State of Illinois
- Licensed Specialty: State of Illinois
Research Highlights:
· Publication #1 Highlighted by several organizations such as Futurity and medicalnewstoday website. https://www.futurity.org/chewing-blood-sugar-type-2-diabetes-2917592/
https://www.medicalnewstoday.com/articles/chewing-properly-may-help-lower-blood-sugar-in-people-with-type-2-diabetes
Reached to 313 of the Altmetric index
· Publication #12 Highlighted on the NIH/NIDCR website
http://www.nidcr.nih.gov/ScienceSpotlight/InterviewsbyTopic/PeriodontalDisease/Early-Onset-Periodontitis-Children.htm
· Publication #13
Featured by MDlinx, http://www.mdlinx.com/dentistry/news-article.cfm/4752615
· Publication #12
o Featured as the on-line cover and in podcast. (Nat Immunology May 2012 13(5). http://www.nature.com/ni/journal/v13/n5/covers/index.html
o (Nat Immunology 2012 13(5):465-473) Highlighted on the NIH/NIDCR website http://www.nidcr.nih.gov/ScienceSpotlight/InterviewsbyTopic/PeriodontalDisease/Hajishengallis.htm.
o Featured in a commentary (Khader, Nat Immunol 2012 doi:10.1038/ni.2290). http://www.nature.com/ni/journal/v13/n5/full/ni.2290.html
o Featured as highlighted news at the This Week in Perio.
http://multibriefs.com/briefs/aaporg/AAPORG080112.php
o Selected as a resident watch article in Journal of Periodontology
http://www.joponline.org/doi/full/10.1902/jop.2012.1210001?prevSearch=eskan&searchHistoryKey=
·Publication #13
(Cell Host & Microbe, 2011 10:497-506) Highlighted on the NIH/NIDCR website http://www.nidcr.nih.gov/Research/ResearchResults/NewsReleases/CurrentNewsReleases/OralBacterium.htm
·Presentation #15.
Awarded the first place in Clinical Competition, Southern Academy of Periodontics, 2011 Palm Coast, Florida
·Presentation #16.
Awarded the first place in oral clinical presentation. American Academy of Osseointegration. 2011 Washington, DC
·Presentation #18.
Selected by American Academy of Osseointegration for clinical competition. 2012 Phoenix, AZ
Publications (cited more than 2700 times):
1- YE Bayram and, MA Eskan. Mastication Inefficiency Due To Diminished or Lack of Occlusal Support is Associated with Increased Blood Glucose Levels in Patients with Type 2 Diabetes PlosOne. 2023 Apr 14;18(4)
2- MA Eskan. A Total Fixed Reconstruction in Patients with Severe Chronic Periodontitis and Requiring Immediate Implant Placement and Loading: A Retrospective Clinical Study Curr Res Dent Sci. 2023; 33(1): 14-19
3- MA Eskan. Implant-Associated Giant Cell Granuloma: A case report of 4.5-year follow up. Selcuk Dental Journal: 2022 Feb 9(1): 231-235
4- YE Bayram and, MA Eskan. A fixed reconstruction of partially edentulous patient with systemic scleroderma: A 4.8-year follow up. Clin. Adv. Periodontics. Jul 1, 2021. Doi:10.1002/cap.10174.
5- MA Eskan, Uzel G, Yilmaz S. A Fixed Reconstruction of Complete Edentulous Patient with Immediate Function Using a New Implant Design: A Retrospective Clinical Study Int J of Implant Dent. 2020 Nov 23;6(1):77
6- Inonu E, Kayis SA, Eskan MA, Dundar N and Hakki SS. Salivary Del-1, IL-17 and LFA-1 Levels in Periodontal Health and Disease J Periodontal Res. 2020 Aug;55(4):511-518
7- MA Eskan, D Morton, E Girouard, H Greenwell. 2017 The Effect of Membrane Exposure on Lateral Ridge Augmentation: A Case Controlled Study. Int J of Implant Dent. 2017 Dec;3(1):26
8- Moutsopoulos, N., J. Konkel, Sarmadi M., Eskan MA., T. Wild, N. Dutzan, L. Abusleme, Zenobia C., Hosur K.B., Abe T., Uzel G., W. Chen, T. Chavakis, Holland SM., and Hajishengallis G. Defective neutrophil recruitment in leukocyte adhesion deficiency Type I causes local IL-17–driven inflammatory bone loss. Science Transl. Med. 6:229ra40 (2014).
9- Eskan MA, and Greenwell H, Hill M, Morton D, Vidal R, Shumway B, Girouard ME. Platelet-rich Plasma Assisted Guided Bone Regeneration for Ridge Augmentation: A Randomized, Controlled, Clinical Trial. J Periodontol. 2013 Jul 29.
10- Eskan MA, and Greenwell H. Massive Gingival Fibrous Lesion Excision Using Acellular Dermal Matrix for Gingival Regeneration: A Case Report. Clin. Adv Periodon April 16, 2013
11- Shumway BS, Eskan MA, Bernstein ML. Recurrent gingival fibrous lesions: comparison of 2 cases and potential need for additional classification. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Apr 10.
12- Eskan MA, Ravi Jotwani, Toshiharu Abe, Jindrich Chmelar, Jong-Hyung Lim, Shuang Liang, Paul A. Ciero, Jennifer L. Krauss, Fenge Li, Martina Rauner, Lorenz C. Hofbauer, Eun Young Choi, Kyoung-Jin Chung, Ahmed Hashim, Michael A. Curtis,Triantafyllos Chavakis, and George Hajishengallis. The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss. Nat Immunol. 2012 May 25;13(5):465-73.
13- Hajishengallis, G., S. Liang, M.A. Payne, A. Hashim, R. Jotwani, Eskan, MA., M.L. McIntosh, A. Alsam, K.L. Kirkwood, J.D. Lambris, R.P. Darveau, and M.A. Curtis. Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota complement. Cell Host & Microbe, Cell Host Microbe. 2011 Nov 17;10(5):497-506
14- Krauss JK, Liang S, McIntosh ML, Eskan MA, and Hajishengallis, G., Mouse models of periodontal host-pathogen interactions and inflammation. 2011 Periodontal Disease-Methods and Protocols.
15- Eskan MA, Greenwell H. Theoretical and Clinical Considerations for Autologous Blood Preparations: Platelet-Rich Plasma, Fibrin Sealants, and Plasma-Rich Growth Factors (review). Clin. Adv. Periodontol. 2011 Aug; 1(2):142-153
16- Benakanakere MR, Li Q, Eskan MA, Singh AV, Zhao J, Galicia JC, Stathopoulou P, Knudsen TB, Kinane DF. Modulation of TLR2 protein expression by miR-105 in human oral keratinocytes. J Biol. Chem. 2009 Aug21;284(34):23107-15
17- Eskan MA, Rose BG, Benakanakere M, Zeng Q, Fujioka D, Martin M, Lee MJ, Kinane DF. S1P and TLR4 Receptors enhance Inflammatory Cytokine Production in Human Gingival Epithelial Cells. Eur. J Immunol. 2008 Apr;38(4):1138-47
18- Eskan MA, Benakanakere M, Rose BG, Zhang P, Stathopoulou P, Fujioka D, Kinane DF. IL-1β modulates proinflammatory cytokine production in human epithelial cells. Infect Immun. 2008 May;76(5):2080-9
19- Eskan MA, Rose BG, Benakanakere M, Lee MJ, Kinane DF. Sphingosine 1-Phosphate 1 (S1P1) and TLR4 receptors mediate IFN-β expression in human gingival epithelial cells. J Immunology. 2008 Feb 1;180(3):1818-25
20- Eskan MA, Hajishengallis, G. & Kinane, DF. Differential Activation of Human Gingival Epithelial Cells and Monocytes by Porphyromonas gingivalis Fimbriae. Infect. Immun. 2007 Feb;75(2):892-8
21- Kinane, DF., H. Shiba, PG. Stathopoulou, H. Zhao, DF. Lappin, A. Singh, Eskan MA, S. Beckers, S. Waigel, B. Alpert, and TB. Knudsen. Gingival epithelial cells heterozygous for Toll-like receptor 4 polymorphisms Asp299Gly and Thr399Ile are hypo-responsive to Porphyromonas gingivalis. Genes Immun. 2006 Apr;7(3):190-200
Abstracts and Presentations:
1) Synergy between TLR4 and S1P1 enhances Oral Epithelial Cell Integrity.
MA Eskan, BG Rose, Q Zeng, MJ Lee and DF Kinane. (Innate Immun, San Antonio, 2006)
2) TLR4 gene variants results in cytokine production differences following Porphyromonas gingivalis challenge. M BENAKANAKERE, MA ESKAN, D FUJIOKA, P ZHANG, PG. STATHOPOULOU, B ROSE, and DF KINANE (Innate Immun, San Antonio, 2006)
3) Differential Activation of Human Gingival Epithelial Cells and Monocytes by Porphyromonas gingivalis. MA Eskan, G Hajishengallis, and DF KinanE (Gordon, Periodontal diseases, Italy, 2006)
4) Common TLR4 polymorphisms influence NALP3 and caspase-1 in epithelial cells. MA ESKAN, M BENAKANAKERE, and DF KINANE (AADR/IADR, New Orleans, 2007)
5) Proinflammatory Responses Elicited by Four Periodontal Bacteria.
P.G. STATHOPOULOU, D. FUJIOKA, MA ESKAN, P ZHANG, M BENAKANAKERE, B ROSE, and DF KINANE (AADR, IADR, New Orleans, 2007)
6) MicroRNAs miR-128a and miR-146a Regulate Cytokines in Gingival Epithelial Cells. M BENAKANAKERE, MA ESKAN, D FUJIOKA, P ZHANG, PG. STATHOPOULOU, B ROSE, and DF. KINANE. (AADR, IADR, New Orleans, 2007)
7) Age-related TLR4 and Sphingosine 1-Phosphate Functionality in Gingival Epithelial Cells. MA ESKAN, B ROSE, Q ZENG, MJ LEE, and DF KINANE (AADR, IADR, New Orleans, 2007)
8) CD14/TLR2 complex induction by P. gingivalis fimbriae in lipid rafts. G.HAJISHENGALLIS , S LIANG 1, MA. ESKAN, M TRIANTAFILOU DF KINANE, and K TRIANTAFILOU (AADR, IADR, New Orleans, 2007)
9) Detecting Periodontal and Oral Bacterial from Blood Samples by qPCR.
P. ZHANG, M BENAKANAKERE, B ROSE, MA ESKAN, D FUJIOKA, PG. STATHOPOULOU, and DF. KINANE (AADR, IADR, New Orleans, 2007)
10) Epithelial TLR4 Levels Correlate With Cytokine and Antimicrobial Peptide Production. DF KINANE, SU GORR, PG. STATHOPOULOU, D FUJIOKA, MA ESKAN, P ZHANG, M BENAKANAKERE, and B ROSE (AADR, IADR, New Orleans 2007)
11) Sphingosine 1-Phosphate and LPS in the induction of Interferon beta in epithelial cells. MA Eskan, BG Rose, M Benakanakere, MJ Lee, DF Kinane (Innate Immunity, Ankara, 2007)
12) Genotypes and systemic inflammatory molecules in experimental gingivitis.
Zhang P, Benakanakere MR, Rose BG, Eskan MA, Stathopoulou P and Kinane DF. (IADR, Toronto, 2008)
13) Sphingosine Kinase 1 regulated HBD-2 induction in oral keratinocytes.
M BENAKANAKERE, Q LI, J ZHAO, MA ESKAN, PG. STATHOPOULOU, J GALICIA, and DF KINANE (IADR, Toronto, 2008)
14) mic-105 modulates TLR2 expression in oral keratinocytes. M BENAKANAKERE, Q LI, J ZHAO, MA ESKAN, PG. STATHOPOULOU, J GALICIA, and DF KINANE. (IADR, Toronto, 2008).
15) Platelet Rich Plasma Assisted Guided Bone Regeneration in Older Patients with an Impaired Healing Response: A Controlled Clinical, Histologic and Biologic Comparison Study in Humans. MA ESKAN, and H GREENWELL. (Southern Academy of Periodontics, 2011,)
16) Ridge preservation comparing the clinical and histologic healing of a mineralized cortical vs. mineralized cancellous allograft with an acellular dermal matrix barrier membrane. MJ, Sam, H. Greenwell, M. Hill, MA Eskan, D. Morton, B. S. Shumway. Academy of Osseointegration (Washington DC, 2011)
17) Developmental endothelial locus–1 (Del-1) is required for periodontal host homeostasis and prevention of IL-17–mediated pathology. Ravi Jotwani, MA ESKAN, Paul A. Ciero, Fenge Li, Shuang Liang, Triantafyllos Chavakis, and George Hajishengallis. (Gordon, Periodontal diseases, Davidson College, Davidson, NC. 2011)
18) Ridge Preservation Comparing Demineralized Particulate Allograft and Mineralized Cancellous Allograft using a PTFE Barrier: A Clinical and Histologic Study in Humans. V. Kotevska, H. Greenwell, M. Hill, MA Eskan, D. Morton, BS. Shumway. American Academy of Osseointegration (Phoenix AZ, 2012)
19) Total Rehabilitation of The Edentulous Patients. MA Eskan. NobelBiocare Academy (Bolu/Turkey, 2013)
20) The Effect of Resorbable Membrane Exposure on Ridge Augmentation: A Clinical Case Series. MA ESKAN, HENRY GREENWELL. American Academy of Osseointegration (Seattle WA, 2014)
21) Fixed Rehabilitation of The Severely Resorbed Edentulous Jaws, Using The All-on-4 Concept. MA Eskan. NobelBiocare Academy (Nove 2014, Antalya/Turkey)
22) Fixed Rehabilitation of the Severely Resorbed Edentulous Jaws. MA Eskan (Nov 2015, Istanbul)
23) A Total Fixed Rehabilitation for the Edentulous Jaws. MA Eskan. ITI TUR/AZA annual meeting (Dec 2015, Antalya/Turkey)
24) Resorbed Edentulous Jaws and Fixed Restorations. MA Eskan. (Feb 2016 Elazig/Turkey)
25) Fixed Rehabilitation of the Severely Resorbed Edentulous Jaws using The Angle Fixed Concept. MA Eskan (March 2016, Ankara/Turkey)
26) Contemporary Management of The Edentulous Patients. MA Eskan (June 2016, Adana/TURKEY)
27) Fixed Rehabilitation of the Severely Resorbed Edentulous Jaws using The Angle Fixed Concept. MA Eskan (Apr 2016, Berlin/Germany)
28) Re-smiling with the Straumann ProArch. MA Eskan (April 2016, Chicago/USA)
29) The Effect of Bioresorbable Membrane Exposure on Ridge Augmentation: A Case Control Study in Human. MA Eskan (Oct 2016, Paris/France)
30) Contemporary Management of The Severely Resorbed Edentulous Jaws. MA Eskan (Oct 2016, Istanbul/TURKEY)
31) Fixed Rehabilitation of The Severely Resorbed Edentulous Jaws. MA Eskan (Dec 2016, Mersin/TURKEY)
32) Increasing The Outcome of Guided Bone Regeneration. MA Eskan (Jan 2017, Ispringen/Germany)
33) Tilting or Not: Total Rehabilitation of The Severely Resorbed Edentulous Jaws. MA Eskan (Feb 2017, Bolu/Turkey)
34) Common Problems and Their Solutions in The Rehabilitation of The Severely Resorbed Complete Edentulous Jaws MA Eskan (Apr 2017, Adana/TURKEY)
35) The Effect of Membrane Exposure on Lateral Ridge Augmentation: A Case Controlled Study. MA Eskan (Sep 2017, AAP Annual Meeting, Boston/USA)
36) The Effect of Membrane Exposure on Lateral Ridge Augmentation. MA Eskan (Sep 2017, Dental Medicine and Dentistry, NY/USA)
37) A Fixed Reconstruction of Complete Edentulos Patient with Immediate Function Using a New Implant Design: A Retrospective Clinical (Sep 2017, Lisbon/Portugal)
38) Age Associated changes in innate immunity and their impact on inflammatory diseases. MA Eskan (Mar 21, 2018. AADR, Fort Lauderdale FL)
39) Complications in the treatment of severely resorbed complete edentulous jaws. MA Eskan (Apr 12, 2018 ITI Study Section, Istanbul)
40) Utilizing Osseodensification in the treatment of complete edentulous patients. MA Eskan (Aug 04, 2018, Versah, Istanbul)
41) The Treatment of Severely Resorbed Complete Edentulous Jaws, Utilizing Versah Burs. MA Eskan (Oct 06, 2018, Meffert Implant Ints, Bodrum, Turkey)
42) A Fixed Reconstruction of Complete Edentulous Patient with Immediate Function Using a New Implant Design: A Retrospective Clinical Study. MA Eskan., G Uzel, S Yilmaz (Mar 14, 2019, American Osseointegration, DC, USA)
43) Effect of the Chewing Function on Controlling The Blood Glucose Level in Patients with Type-2 Diabetes. EY Bayram and MA Eskan. Annual Internal Medicine Meeting Antalya, Turkey Jun 4 2022.
44) Chewing function and controlling blood glucose level. 2 hr CE credit. University of Buffalo School of Dental Medicine. Oct 4, 2023
45) The effect of mastication on HbA1c in type -2 diabetic patients. 1 hr CE credit. ISOP annual meeting, Feb 22, 2024